ABSTRACT
For kindergarten children, distance education was neither an alternative nor a potential option to in-person schooling before the global COVID-19 pandemic-imposed isolation and mandatory social distancing measures. These measures guaranteed the safety of school staff and children and made the adoption of distance education an urgent necessity for children to continue their education safely. The current study was conducted to reveal the most common challenges that faced children's distance education in virtual kindergartens. The study was conducted from the teachers' point of view to determine the impact of each of the job title variables and years of experience. The study sample consisted of 32 kindergarten teachers in Jubail Governorate. The research team applied the scale of challenges facing children's education in virtual kindergarten. The results of the study concluded that the most important challenges facing children's education in virtual kindergartens were related to communication skills (79.9%), technical skills (79.5%), educational aids (76.4%), and motivation (69.6%). The results of the study also revealed that there were statistically significant differences in the challenges related to motivation and readiness and in the total challenges facing children's education in the virtual kindergarten from the teachers' point of view depending on the job title—that is, the assistant teacher where the calculated "U” value reached 28.5 and 37.5. In addition, there was an absence of statistically significant differences due to the variable years of experience, whether in the total number of challenges or in the dimensions of the scale, except for the dimension of communication skills, where the calculated "Ka2” value reached 8.755, which is a statistically significant value at the level of significance (0.05). © 2023 NSP.
ABSTRACT
The rapid transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-driven infection signifies an ultimate challenge to global health, and the development of effective strategies for preventing and/or mitigating its effects are of the utmost importance. In the current study, an in-depth investigation for the understanding of the SARS-CoV-2 inactivation route using graphene oxide (GO) is presented. We focus on the antiviral effect of GO nanosheets on three SARS-CoV-2 strains: Wuhan, B.1.1.7 (U.K. variant), and P.1 (Brazilian variant). Plaque assay and real-time reverse transcription-polymerase chain reaction (RT-PCR) showed that 50 and 98% of the virus in a supernatant could be cleared following incubation with GO (100 μg/mL) for 1 and 60 min, respectively. Transmission electron microscopy (TEM) analysis and protein (spike (S) and nucleocapsid (N) proteins) decomposition evaluation confirm a two-step virus inactivation mechanism that includes (i) adsorption of the positively charged spike of SARS-CoV-2 on the negatively charged GO surface and (ii) neutralization/inactivation of the SARS-CoV-2 on the surface of GO through decomposition of the viral protein. As the interaction of S protein with human angiotensin-converting enzyme 2 (ACE2) is required for SARS-CoV-2 to enter into human cells, the damage to the S protein using GO makes it a potential candidate for use in contributing to the inhibition of the worldwide spread of SARS-CoV-2. Specifically, our findings provide the potential for the construction of an effective anti-SARS-CoV-2 face mask using a GO nanosheet, which could contribute greatly to preventing the spread of the virus. In addition, as the effect of surface contamination can be severe in the spreading of SARS-CoV-2, the development of efficient anti-SARS-CoV-2 protective surfaces/coatings based on GO nanosheets could play a significant role in controlling the spread of the virus through the utilization of GO-based nonwoven cloths, filters, and so on. © 2021 American Chemical Society.